Isabelle Vernos

Research and Interests

Dr. Vernos has a long-standing interest in understanding the complex mechanisms and signaling pathways that coordinate the transient formation of mitotic spindles, i.e. the microtubule-based molecular machines that segregate the chromosomes during cell division. Her research specifically focuses on elucidating and identifying the complex protein networks involved in the formation of microtubule. In addition, she studies the dynamic interactions between microtubule-dependent molecular motors and chromosomes during cell division. Cell division is a life critical process, and perturbations of it may lead to cell death, abnormal proliferation and developmental defects. A thorough understanding of the mechanisms controlling cell division may thus lead to the discovery of new ways to diagnose and treat cancer, fertility and other major disorders, in which perturbations of cell division play a role.

Expertise and Capabilities

Vernos’ group is an expert in the use of the Xenopus egg extract cell-free system combined with cutting-edge microscopy for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behavior, which they combine with the use of human tissue culture cells to validate the results obtained in the egg extract. They also use the latest genomics and proteomics techniques in combination with classical biochemical and molecular biology.

Additional Information

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