Toni Gabaldon Estevan
Research and Interests
Dr. Gabaldon’s main interest is the complex relationship between genome sequences and phenotypes and how these two features evolve across species. With large-scale phylogenetic approaches, he focuses on the evolution and function of organelles, pathways, and protein families. Next to addressing fundamental evolutionary processes in cell death pathways and the involvement of cell organelles in this respect, he studies processes in relation to fungal infectious diseases and organelle-related genetic diseases such as Parkinson, Alzheimer and Huntington disease. Understanding how cellular organelles, biochemical pathways or protein complexes emerge and evolve, will provide great insight into their function and possible role in diseases.
Expertise and Capabilities
Dr. Gabaldón's research utilizes comparative genomics and phylogenomics to study the origin, evolution and function of complex biological systems through collaboration with different experimental groups. Specifically, through the development of novel bioinformatics tools and algorithms, the group addresses:
- Comparative genomics of fungal pathogens;
- Discovery of new genes involved in mitochondrial-related disease;
- Comparative genomics of apoptosis and other eukaryotic programmed cell death pathways (Deathbase);
- Origin and evolution of eukaryotic organelles such as mitochondria and peroxisome;
- Phylogenomics and genome evolution through large-scale phylogenetics (TrimAI, TreeKO, ETE, PhylomeDB, MetaPhOrs).
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